iTriplet, a rule-based nucleic acid sequence motif finder
نویسندگان
چکیده
منابع مشابه
Sensitivity and Specificity of Nucleic Acid Sequence-Based Amplification Method for Diagnosis of Cutaneous Leishmaniasis
Abstract Background and Objective: Culture, microscopic method is a gold standard method for identification of Lishmania parasite. The use of Molecular methods such as RT- PCR compared to microscopic methods has a higher sensitivity and specificity however, it is not widely used due to its expensive equipment and the time requested. The use of nucleic acid sequence based amplification (NASBA) ...
متن کاملThe NestedMICA motif finder
NestedMICA is a new, scalable, pattern-discovery system, aimed at finding transcription factor binding sites and similar motifs in biological sequence. More discussion of the principles behind NestedMICA, and an evaluation of its sensitivity can be found in a recent paper [1]. If you have any problems or questions about the system, please contact Thomas Down.
متن کاملNucleic Acid i-Motif Structures in Analytical Chemistry.
Under the appropriate experimental conditions of pH and temperature, cytosine-rich segments in DNA or RNA sequences may produce a characteristic folded structure known as an i-motif. Besides its potential role in vivo, which is still under investigation, this structure has attracted increasing interest in other fields due to its sharp, fast and reversible pH-driven conformational changes. This ...
متن کاملFundamental aspects of the nucleic acid i-motif structures
The i-motif structure is formed in cytosine-rich sequences, being its building block the cytosine•cytosine+ base pair. This structure is particularly stable at pH values below the physiological one (~7.4) and, because of that, it has not attracted as much biological interest as other non-canonical structures such as the G-quadruplex. Nowadays, the proposal of potential roles in vivo, as well as...
متن کاملThe 'helix clamp' in HIV-1 reverse transcriptase: a new nucleic acid binding motif common in nucleic acid polymerases.
Amino acid sequences homologous to 259KLVGKL (X)16KLLR284 of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) are conserved in several nucleotide polymerizing enzymes. This amino acid motif has been identified in the crystal structure model as an element of the enzyme's nucleic acid binding apparatus. It is part of the helix-turn-helix structure, alpha H-turn-alpha I, within...
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ژورنال
عنوان ژورنال: Algorithms for Molecular Biology
سال: 2009
ISSN: 1748-7188
DOI: 10.1186/1748-7188-4-14